Cyp17a2 enhances antiviral responses in male zebrafish by stabilizing STING through TRIM11-mediated K33-linked polyubiquitination, boosting IFN production.
Thousands of bacterial and other microbial species live in the human gut, supporting healthy digestion, immunity, metabolism and other functions. Precisely how these microbes are protected from immune ...
This illustration depicts as human STING protein signaling progresses from inactive to overactive, it can trigger an unwanted immune response — a progression not found in mouse models. Researchers ...
A new breakthrough from researchers at the University of Cambridge removes the dangers involved in a process called STING, in which the body's own immune system can be enlisted to fight cancer. The ...
China Pharmaceutical University and Chongqing Innovation Institute China Pharmaceutical University have reported tetrahydronaphthyridine compounds acting as stimulator of interferon genes protein ...