The final guidance explains some principles for developing biosimilars and establishes some rules about extrapolation across indications for various medical conditions. EMA released final guidance on ...

Some of the most widely used biologic medicines in oncology have patents about to expire, opening the market to noninnovative versions of these drugs. There are already many examples of price ...

Marcinkiewicz integral operators constitute a central class of singular integral operators in modern harmonic analysis. These operators, defined through oscillatory integrals with rough kernels, play ...

Survival extrapolation plays a pivotal role in cost-effectiveness analysis by extending observed clinical trial data to estimate long-term patient outcomes. Given that the follow‐up periods of trials ...

This is a preview. Log in through your library . Abstract We demonstrate that relatively high revenue growth prior to an initial public offering (IPO) is associated with high IPO prices and poor ...