UT Southwestern Medical Center researchers have identified two lipids that work together with a quintessential protein known ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens, T cell ...

Effect of MP0317, a FAP x CD40 DARPin, on safety profile and tumor-localized CD40 activation in a phase 1 study in patients with advanced solid tumors. Efficacy, safety, and PK/PD of LVGN6051, 4-1BB ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Immunotherapies have greatly improved the outcomes of many patients with melanoma. But there is still a need for new approaches for the subset of patients who do not respond well to this type of ...

This illustration depicts as human STING protein signaling progresses from inactive to overactive, it can trigger an unwanted immune response — a progression not found in mouse models. Researchers ...

Researchers can use messenger RNA to trigger the immune system to attack tumors. By stimulating cancer cells to produce a molecule that activates a signaling pathway in nearby immune cells, MIT (MA, ...